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  • Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Macromolecular bioscience (2011-12-15)
Thimma R Thatiparti, Nicole Averell, Derek Overstreet, Horst A von Recum
ABSTRACT

A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, and the drug release properties of dimeric coumermycin are compared to novobiocin with only one biding domain. The drugs are loaded into affinity-based and diffusion-only delivery platforms, the loading efficiency is calculated, and the release kinetics is determined in vitro. The presence of additional binding domains prolongs the release of antibiotics. Release rates differ little between modified and unmodified drug from the diffusion-only system. The results demonstrate the feasibility of custom-tuning drug delivery by multiplexing interactions with an affinity-based polymer platform.

MATERIALS
Product Number
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Product Description

Sigma-Aldrich
Novobiocin sodium salt, ≥90% (HPLC)
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100 μL
Estimated to ship on March 21, 2025
MXP 12,107.00
Sigma-Aldrich
Novobiocin sodium, meets USP testing specifications
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100 μL
Estimated to ship on March 21, 2025
MXP 12,107.00
Sigma-Aldrich
Coumermycin A1
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100 μL
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MXP 12,107.00
Supelco
Novobiocin sodium salt, VETRANAL®, analytical standard
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SKUPack SizeAvailabilityPriceQuantity
100 μL
Estimated to ship on March 21, 2025
MXP 12,107.00