- Synthesis of 3-N-sugar-substituted-2, 4(1H,3H)-quinazolinedionesas anti-angiogenesis agents.
Synthesis of 3-N-sugar-substituted-2, 4(1H,3H)-quinazolinedionesas anti-angiogenesis agents.
Molecules (Basel, Switzerland) (2009-07-28)
Conghai Huang, Xiangbao Meng, Jingrong Cui, Zhongjun Li
PMID19633615
ABSTRACT
A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.