T2943

Tissue plasminogen activator chromogenic substrate

≥95% (HPLC), solid

• Synonym(s): TPA Activity Assay
• MDL number: MFCD03458748
• UNSPSC Code: 12352204
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: solid
• mol wt: apparent mol wt 658.9
• solubility: methanol: water (1:9): 25 mg/mL
• storage temp.: 2-8°C

Description

General description

Tissue plasminogen activator chromogenic substrate is a highly sensitive chromogenic peptide substrate for tissue plasminogen activator (tPA). It shows different sensitivity to native single-chain tPA (sc-tPA) and its fully active two-chain form (tc-tPA).

Application

Tissue plasminogen activator chromogenic substrate has been used:

• in tissue plasminogen activator inhibition assay
• to determine the plasminogen activator (PA) activity by studying the glycosylation properties of tissue plasminogen activator (tPA) activities in effusions using concanavalin A-Sepharose (conA-S) chromatography
• in inhibition assays and complex formation analyses of wild type (WT) neuroserpin (NS) and its variants

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves