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Merck

C3050

Sigma-Aldrich

Cephalothin sodium salt

BioReagent, suitable for cell culture

Synonym(s):

7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt

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About This Item

Empirical Formula (Hill Notation):
C16H15N2NaO6S2
CAS Number:
Molecular Weight:
418.42
Beilstein:
4120706
EC Number:
MDL number:
UNSPSC Code:
51101500
PubChem Substance ID:

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product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

water: 50 mg/mL, clear, colorless to light yellow

antibiotic activity spectrum

Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O

InChI

1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1

InChI key

VUFGUVLLDPOSBC-XRZFDKQNSA-M

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General description

Cephalotin is a first generation cephalosporin antibiotic.
Chemical structure: ß-lactam

Biochem/physiol Actions

Mode of Action: Inhibits cell wall synthesis.
Antimicrobial spectrum: Gram-positive cocci.
Mode of Resistance: Cephalosporinase production.
Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Jung-Whan Chon et al.
Journal of food science, 77(7), M354-M358 (2012-06-08)
A total of 115 desiccated food samples, including agricultural and marine products, were investigated for the presence of Cronobacter. Cronobacter species were characterized with biochemical tests. Antibiotic resistance was assessed with the disk diffusion method, and the molecular subtypes of
Sarah M Drawz et al.
Biochemistry, 49(2), 329-340 (2009-11-21)
The need to develop beta-lactamase inhibitors against class C cephalosporinases of Gram-negative pathogens represents an urgent clinical priority. To respond to this challenge, five boronic acid derivatives, including a new cefoperazone analogue, were synthesized and tested against the class C
Angela Gomes de Vasconcellos et al.
Japanese journal of infectious diseases, 65(1), 7-12 (2012-01-26)
Cellulitis is an important cause of hospitalization in pediatrics. Because Staphylococcus aureus is the main pathogen of cellulitis, medicinal therapeutics should take the changing resistance profile of this organism into consideration. The aim of this study was to evaluate the
Bulent Tokgoz et al.
Renal failure, 32(2), 179-184 (2010-03-05)
Aminoglycosides have been used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. The ototoxicity risk of intraperitoneally administered aminoglycosides has been investigated by a number of studies. However, their results are somewhat conflicting. The aim of
Reply: Protective effect of topical antibiotics in breast augmentation.
Philip K Pfeiffer et al.
Plastic and reconstructive surgery, 131(1), 115e-115e (2012-12-29)

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