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Merck

C3050

Sigma-Aldrich

Cephalothin Natriumsalz

BioReagent, suitable for cell culture

Synonym(e):

7-(2-Thienylacetamino)-cephalosporansäure Natriumsalz, Cephalotin Natriumsalz

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About This Item

Empirische Formel (Hill-System):
C16H15N2NaO6S2
CAS-Nummer:
Molekulargewicht:
418.42
Beilstein:
4120706
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51101500
PubChem Substanz-ID:

Produktlinie

BioReagent

Form

powder

Methode(n)

cell culture | mammalian: suitable

Löslichkeit

water: 50 mg/mL, clear, colorless to light yellow

Wirkungsspektrum von Antibiotika

Gram-positive bacteria

Wirkungsweise

cell wall synthesis | interferes

Lagertemp.

2-8°C

SMILES String

[Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O

InChI

1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1

InChIKey

VUFGUVLLDPOSBC-XRZFDKQNSA-M

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Allgemeine Beschreibung

Cephalotin is a first generation cephalosporin antibiotic.
Chemical structure: ß-lactam

Biochem./physiol. Wirkung

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.
Mode of Action: Inhibits cell wall synthesis.
Antimicrobial spectrum: Gram-positive cocci.
Mode of Resistance: Cephalosporinase production.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Piktogramme

Health hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Die Dokumentenbibliothek aufrufen

Esteban C Nannini et al.
Antimicrobial agents and chemotherapy, 54(5), 2206-2208 (2010-03-10)
Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no
Eduardo Bracho-Blanchet et al.
Cirugia y cirujanos, 77(4), 279-285 (2009-11-19)
There are few randomized clinical trials that prove the effectiveness of antibiotic prophylaxis (AP) to prevent pediatric surgical site infections (SSI). We undertook this study to determine the effectiveness of AP vs. traditional scheme of antibiotics. We carried out a
Joel Veiga-Filho et al.
Annals of plastic surgery, 65(2), 144-146 (2010-06-30)
This prospective study was conducted to assess the influence of antibiotics use on surgical site infections (SSI) rates after reduction mammaplasty. Patients undergoing reduction mammaplasty were assigned to group 1 (n = 50), which received intravenous cephalotin pre- and postoperatively
Protective effect of topical antibiotics in breast augmentation.
Zhiyong Lan et al.
Plastic and reconstructive surgery, 131(1), 114e-115e (2012-12-29)
Marina Pană et al.
Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990), 55(2), 95-102 (2011-05-11)
The aim of the this study was the analysis of the resistance to antibiotics of Streptococcus pneumoniae isolated in last years. 328 S. pneumoniae strains, coming from blood, CSF tracheal aspirate (TA), or sputum, pleural fluid (PL) and other samples

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