WNT4
wingless-type MMTV integration site family, member 4
Synonyms:
SERKAL, WNT-4
Species:
Human WNT4 (54361), Mouse Wnt4 (22417), Rat Wnt4 (84426), fruit fly Wnt4 (34007), dog WNT4 (612367), chicken WNT4 (395561), cow WNT4 (789600), Horse WNT4 (100071678), domestic cat WNT4 (101095185), sheep WNT4 (101122423) ...More
UniProtKB ID:
Gene ID:
- Human(54361) Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
- Mouse(22417) wingless-related MMTV integration site 4
- Rat(84426) wingless-type MMTV integration site family, member 4
- fruit fly(34007) Wnt oncogene analog 4
- dog(612367) wingless-type MMTV integration site family, member 4
- chicken(395561) wingless-type MMTV integration site family, member 4
- cow(789600) wingless-type MMTV integration site family, member 4
- Horse(100071678) wingless-type MMTV integration site family, member 4
- domestic cat(101095185) wingless-type MMTV integration site family, member 4
- sheep(101122423) wingless-type MMTV integration site family, member 4
- naked mole-rat(101701972) wingless-type MMTV integration site family, member 4
- domestic guinea pig(100724855) wingless-type MMTV integration site family, member 4
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