TDP1
tyrosyl-DNA phosphodiesterase 1
Synonyms:
Species:
Human TDP1 (55775), Mouse Tdp1 (104884), Rat Tdp1 (314380), Thale Cress TDP1 (831369), domestic guinea pig Tdp1 (100724667), naked mole-rat Tdp1 (101712310), domestic cat TDP1 (101093528), Horse TDP1 (100062463), cow TDP1 (517053), sheep TDP1 (101119906) ...More
UniProtKB ID:
Gene ID:
- Human(55775) Summary: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]
- Mouse(104884) tyrosyl-DNA phosphodiesterase 1
- Rat(314380) tyrosyl-DNA phosphodiesterase 1
- Thale Cress(831369) tyrosyl-DNA phosphodiesterase 1
- domestic guinea pig(100724667) tyrosyl-DNA phosphodiesterase 1
- naked mole-rat(101712310) tyrosyl-DNA phosphodiesterase 1
- domestic cat(101093528) tyrosyl-DNA phosphodiesterase 1
- Horse(100062463) tyrosyl-DNA phosphodiesterase 1
- cow(517053) tyrosyl-DNA phosphodiesterase 1
- sheep(101119906) tyrosyl-DNA phosphodiesterase 1
- Domestic Rabbit(100349532) tyrosyl-DNA phosphodiesterase 1
- Zebrafish(571485) tyrosyl-DNA phosphodiesterase 1
- chicken(423403) tyrosyl-DNA phosphodiesterase 1
- dog(490828) tyrosyl-DNA phosphodiesterase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
esiRNA
Product Number
Description
Species