STARD5
StAR-related lipid transfer (START) domain containing 5
Synonyms:
Species:
Human STARD5 (80765), Mouse Stard5 (170460), Rat Stard5 (502348), dog STARD5 (100685077), sheep STARD5 (101117196), domestic guinea pig Stard5 (100721449), chicken STARD5 (770108), naked mole-rat Stard5 (101711923), cow STARD5 (512369)
UniProtKB ID:
Gene ID:
- Human(80765) Summary: Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]
- Mouse(170460) StAR-related lipid transfer (START) domain containing 5
- Rat(502348) StAR-related lipid transfer (START) domain containing 5
- dog(100685077) StAR-related lipid transfer (START) domain containing 5
- sheep(101117196) StAR-related lipid transfer (START) domain containing 5
- domestic guinea pig(100721449) StAR-related lipid transfer (START) domain containing 5
- chicken(770108) StAR-related lipid transfer (START) domain containing 5
- naked mole-rat(101711923) StAR-related lipid transfer (START) domain containing 5
- cow(512369) StAR-related lipid transfer (START) domain containing 5
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