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Merck

SNTA1

syntrophin, alpha 1

Synonyms:
LQT12, SNT1, TACIP1, dJ1187J4.5
Species:
Human SNTA1 (6640), Mouse Snta1 (20648), Rat Snta1 (362242), sheep SNTA1 (101109469), Domestic Rabbit SNTA1 (100009179), cow SNTA1 (527488), domestic cat SNTA1 (101098944), dog SNTA1 (485837), domestic guinea pig Snta1 (100732931), naked mole-rat Snta1 (101721241)
UniProtKB ID:
Q13424, A8K7H9, E1P5N1, Q16438
Gene ID:
  • Human(6640) Summary: Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
  • Mouse(20648) syntrophin, acidic 1
  • Rat(362242) syntrophin, alpha 1
  • sheep(101109469) syntrophin, alpha 1
  • Domestic Rabbit(100009179) syntrophin, alpha 1
  • cow(527488) syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
  • domestic cat(101098944) syntrophin, alpha 1
  • dog(485837) syntrophin, alpha 1
  • domestic guinea pig(100732931) syntrophin, alpha 1
  • naked mole-rat(101721241) syntrophin, alpha 1

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Antibodies

Product Number
Description
Species Reactivity
Application
S4813
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit, buffered aqueous solution, IgG fraction of antiserum,
Species Reactivity
rat
Application
immunohistochemistry
microarray
western blot