SLC25A27
solute carrier family 25, member 27
Synonyms:
UCP4
Species:
Human SLC25A27 (9481), Mouse Slc25a27 (74011), Rat Slc25a27 (85262), cow SLC25A27 (536813), Domestic Rabbit SLC25A27 (100347746), naked mole-rat Slc25a27 (101718888), sheep SLC25A27 (101115998), Zebrafish slc25a27 (393312), domestic cat SLC25A27 (101100134), dog SLC25A27 (609887)
UniProtKB ID:
Gene ID:
- Human(9481) Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
- Mouse(74011) solute carrier family 25, member 27
- Rat(85262) solute carrier family 25, member 27
- cow(536813) solute carrier family 25, member 27
- Domestic Rabbit(100347746) solute carrier family 25, member 27
- naked mole-rat(101718888) solute carrier family 25, member 27
- sheep(101115998) solute carrier family 25, member 27
- Zebrafish(393312) solute carrier family 25, member 27
- domestic cat(101100134) solute carrier family 25, member 27
- dog(609887) solute carrier family 25, member 27
- domestic guinea pig(100727789) solute carrier family 25, member 27
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