SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Synonyms:
BSC1, NKCC2
Species:
Human SLC12A1 (6557), Mouse Slc12a1 (20495), Rat Slc12a1 (25065), Domestic Rabbit SLC12A1 (100328575), sheep SLC12A1 (101111371), domestic guinea pig Slc12a1 (100716647), naked mole-rat Slc12a1 (101719170), chicken SLC12A1 (415433), Zebrafish slc12a1 (100329975), dog SLC12A1 (478292) ...More
UniProtKB ID:
Gene ID:
- Human(6557) Summary: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
- Mouse(20495) solute carrier family 12, member 1
- Rat(25065) solute carrier family 12 (sodium/potassium/chloride transporter), member 1
- Domestic Rabbit(100328575) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- sheep(101111371) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- domestic guinea pig(100716647) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- naked mole-rat(101719170) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- chicken(415433) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- Zebrafish(100329975) solute carrier family 12, member 1
- dog(478292) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- domestic cat(101100216) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
- cow(407161) solute carrier family 12 (sodium/potassium/chloride transporters), member 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SLC12A1 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Na+/K+/Cl- Cotransporter 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
ELISA
western blot
western blot
Anti-Na+K+Cl- Cotransporter 2 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
western blot
Monoclonal Anti-SLC12A1 antibody produced in mouse, clone 4H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Torasemide for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Etacrynic acid for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human