PCSK2
proprotein convertase subtilisin/kexin type 2
Synonyms:
NEC 2, NEC-2, NEC2, PC2, SPC2
Species:
Human PCSK2 (5126), Mouse Pcsk2 (18549), Rat Pcsk2 (25121), Zebrafish pcsk2 (100004460), domestic cat PCSK2 (101098130), naked mole-rat Pcsk2 (101710029), domestic guinea pig Pcsk2 (100727607), chicken PCSK2 (395136), dog PCSK2 (485757), Domestic Rabbit PCSK2 (100358339) ...More
UniProtKB ID:
Gene ID:
- Human(5126) Summary: This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
- Mouse(18549) proprotein convertase subtilisin/kexin type 2
- Rat(25121) proprotein convertase subtilisin/kexin type 2
- Zebrafish(100004460) proprotein convertase subtilisin/kexin type 2
- domestic cat(101098130) proprotein convertase subtilisin/kexin type 2
- naked mole-rat(101710029) proprotein convertase subtilisin/kexin type 2
- domestic guinea pig(100727607) proprotein convertase subtilisin/kexin type 2
- chicken(395136) proprotein convertase subtilisin/kexin type 2
- dog(485757) proprotein convertase subtilisin/kexin type 2
- Domestic Rabbit(100358339) proprotein convertase subtilisin/kexin type 2
- Horse(100050755) proprotein convertase subtilisin/kexin type 2
- cow(281968) proprotein convertase subtilisin/kexin type 2
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