OPTN
optineurin
ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Human OPTN (10133), Mouse Optn (71648), Rat Optn (246294), domestic guinea pig Optn (100722896), naked mole-rat Optn (101725616), domestic cat OPTN (101087414), cow OPTN (534150), sheep OPTN (101106703), chicken OPTN (374079), dog OPTN (478003)
- Human(10133) Summary: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- Mouse(71648) optineurin
- Rat(246294) optineurin
- domestic guinea pig(100722896) optineurin
- naked mole-rat(101725616) optineurin
- domestic cat(101087414) optineurin
- cow(534150) optineurin
- sheep(101106703) optineurin
- chicken(374079) optineurin
- dog(478003) optineurin
- Zebrafish(336159) optineurin
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
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Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Anti-OPTN (ab2) antibody produced in rabbit, affinity isolated antibody,
guinea pig, human
western blot
Anti-OPTN antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
human
immunofluorescence
western blot
western blot
Anti-OPTN antibody produced in rabbit, affinity isolated antibody,
dog, guinea pig, horse, human, mouse, rabbit, rat
western blot