NAIP
NLR family, apoptosis inhibitory protein
Synonyms:
BIRC1, NLRB1, psiNAIP
Species:
Human NAIP (4671), sheep NAIP (101110450), naked mole-rat Naip (101706505), cow NAIP (539780), Horse NAIP (100073304), domestic cat NAIP (101090330), domestic guinea pig Naip (100734671)
UniProtKB ID:
Gene ID:
- Human(4671) Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- sheep(101110450) NLR family, apoptosis inhibitory protein
- naked mole-rat(101706505) NLR family, apoptosis inhibitory protein
- cow(539780) NLR family, apoptosis inhibitory protein
- Horse(100073304) NLR family, apoptosis inhibitory protein
- domestic cat(101090330) NLR family, apoptosis inhibitory protein
- domestic guinea pig(100734671) NLR family, apoptosis inhibitory protein
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