MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Synonyms:
MSR, cblE
Species:
Human MTRR (4552), Mouse Mtrr (210009), Rat Mtrr (290947), domestic guinea pig Mtrr (100732821), Zebrafish mtrr (560667), chicken MTRR (428502), sheep MTRR (101123409), Domestic Rabbit MTRR (100350605), cow MTRR (507991), domestic cat MTRR (101098359) ...More
UniProtKB ID:
Gene ID:
- Human(4552) Summary: Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
- Mouse(210009) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- Rat(290947) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- domestic guinea pig(100732821) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- Zebrafish(560667) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- chicken(428502) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- sheep(101123409) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- Domestic Rabbit(100350605) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- cow(507991) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- domestic cat(101098359) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- dog(478623) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
- naked mole-rat(101720530) 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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