Skip to Content
Merck

MAP3K3

mitogen-activated protein kinase kinase kinase 3

Synonyms:
MAPKKK3, MEKK3
Species:
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), cow MAP3K3 (508943), Horse MAP3K3 (100064751), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), domestic cat MAP3K3 (101083633), dog MAP3K3 (480481) ...More
UniProtKB ID:
Q99759, B2RCW2, D3DU15, Q5BKZ6, Q8N3I9
Gene ID:
  • Human(4215) Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(26406) mitogen-activated protein kinase kinase kinase 3
  • Rat(303604) mitogen activated protein kinase kinase kinase 3
  • cow(508943) mitogen-activated protein kinase kinase kinase 3
  • Horse(100064751) mitogen-activated protein kinase kinase kinase 3
  • naked mole-rat(101704335) mitogen-activated protein kinase kinase kinase 3
  • domestic guinea pig(100731994) mitogen-activated protein kinase kinase kinase 3
  • sheep(101122537) mitogen-activated protein kinase kinase kinase 3
  • domestic cat(101083633) mitogen-activated protein kinase kinase kinase 3
  • dog(480481) mitogen-activated protein kinase kinase kinase 3
  • chicken(419954) mitogen-activated protein kinase kinase kinase 3
  • Zebrafish(560211) mitogen-activated protein kinase kinase kinase 3

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.