IYD
iodotyrosine deiodinase
Synonyms:
C6orf71, DEHAL1, TDH4, dJ422F24.1
Species:
Human IYD (389434), Mouse Iyd (70337), Rat Iyd (308129), naked mole-rat Iyd (101721889), domestic guinea pig Iyd (100728406), sheep IYD (101123564), Zebrafish iyd (568107), domestic cat IYD (101100136), dog IYD (476244), chicken IYD (421631)
UniProtKB ID:
Gene ID:
- Human(389434) Summary: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- Mouse(70337) iodotyrosine deiodinase
- Rat(308129) iodotyrosine deiodinase
- naked mole-rat(101721889) iodotyrosine deiodinase
- domestic guinea pig(100728406) iodotyrosine deiodinase
- sheep(101123564) iodotyrosine deiodinase
- Zebrafish(568107) iodotyrosine deiodinase
- domestic cat(101100136) iodotyrosine deiodinase
- dog(476244) iodotyrosine deiodinase
- chicken(421631) iodotyrosine deiodinase
- cow(534110) iodotyrosine deiodinase
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