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Merck

HDAC3

histone deacetylase 3

Synonyms:
HD3, RPD3, RPD3-2
Species:
UniProtKB ID:
Gene ID:
  • Human(8841) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
  • Mouse(15183) histone deacetylase 3
  • Rat(84578) histone deacetylase 3
  • fruit fly(44446) Histone deacetylase 3
  • Zebrafish(393965) histone deacetylase 3
  • cow(404125) histone deacetylase 3
  • chicken(395506) histone deacetylase 3
  • sheep(101107092) histone deacetylase 3
  • domestic guinea pig(100718985) histone deacetylase 3
  • dog(478040) histone deacetylase 3
  • domestic cat(101100941) histone deacetylase 3
  • naked mole-rat(101708680) histone deacetylase 3

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-HDAC3 (pSer424) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-HDAC3 antibody produced in mouse, clone 3E11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-HDAC3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-HDAC3 Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-HDAC3 (pSer424) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
SAHA, ≥98% (HPLC),
Species
human
CI−994, ≥98% (HPLC), powder,
Species
human
Romidepsin, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
HDAC3 human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Hdac3,
Species
mouse