FDPS
farnesyl diphosphate synthase
Synonyms:
FPPS, FPS
Species:
Human FDPS (2224), Mouse Fdps (110196), Rat Fdps (83791), domestic cat FDPS (101086533), Horse FDPS (100063641), cow FDPS (281156), sheep FDPS (101119093), dog FDPS (480129), domestic guinea pig Fdps (100717025), naked mole-rat Fdps (101721614) ...More
UniProtKB ID:
Gene ID:
- Human(2224) Summary: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
- Mouse(110196) farnesyl diphosphate synthetase
- Rat(83791) farnesyl diphosphate synthase
- domestic cat(101086533) farnesyl diphosphate synthase
- Horse(100063641) farnesyl diphosphate synthase
- cow(281156) farnesyl diphosphate synthase
- sheep(101119093) farnesyl diphosphate synthase
- dog(480129) farnesyl diphosphate synthase
- domestic guinea pig(100717025) farnesyl diphosphate synthase
- naked mole-rat(101721614) farnesyl diphosphate synthase
- Zebrafish(552997) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
- chicken(425061) farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
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Small Molecule - Inhibitor
Product Number
Description
Species
Alendronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human