ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Synonyms:
COFS4, RAD10, UV20
Species:
Human ERCC1 (2067), Mouse Ercc1 (13870), Rat Ercc1 (292673), sheep ERCC1 (101116856), domestic cat ERCC1 (101095455), Thale Cress ERCC1 (819685), Zebrafish ercc1 (100001425), domestic guinea pig Ercc1 (100734416), cow ERCC1 (615637), dog ERCC1 (612282) ...More
UniProtKB ID:
Gene ID:
- Human(2067) Summary: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
- Mouse(13870) excision repair cross-complementing rodent repair deficiency, complementation group 1
- Rat(292673) excision repair cross-complementing rodent repair deficiency, complementation group 1
- sheep(101116856) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- domestic cat(101095455) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- Thale Cress(819685) DNA excision repair protein ERCC-1
- Zebrafish(100001425) excision repair cross-complementing rodent repair deficiency, complementation group 1
- domestic guinea pig(100734416) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- cow(615637) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- dog(612282) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
- fruit fly(36654) CG10215 gene product from transcript CG10215-RA
- naked mole-rat(101699727) excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ERCC1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-ERCC1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL1249, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry