DOCK3
dedicator of cytokinesis 3
Synonyms:
MOCA, PBP
Species:
Human DOCK3 (1795), Mouse Dock3 (208869), Rat Dock3 (315992), chicken DOCK3 (415919), Zebrafish dock3 (100536057), domestic guinea pig Dock3 (100734379), naked mole-rat Dock3 (101718931), Domestic Rabbit DOCK3 (100341267), sheep DOCK3 (101114650), dog DOCK3 (476610) ...More
UniProtKB ID:
Gene ID:
- Human(1795) Summary: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins]
- Mouse(208869) dedicator of cyto-kinesis 3
- Rat(315992) dedicator of cyto-kinesis 3
- chicken(415919) dedicator of cytokinesis 3
- Zebrafish(100536057) dedicator of cytokinesis 3
- domestic guinea pig(100734379) dedicator of cytokinesis 3
- naked mole-rat(101718931) dedicator of cytokinesis 3
- Domestic Rabbit(100341267) dedicator of cytokinesis 3
- sheep(101114650) dedicator of cytokinesis 3
- dog(476610) dedicator of cytokinesis 3
- domestic cat(101090678) dedicator of cytokinesis 3
- Horse(100061408) dedicator of cytokinesis 3
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