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Merck

CPSF4

cleavage and polyadenylation specific factor 4, 30kDa

Synonyms:
CPSF30, NAR, NEB1
Species:
Human CPSF4 (10898), Mouse Cpsf4 (54188), Rat Cpsf4 (304277), domestic guinea pig Cpsf4 (100722077), domestic cat CPSF4 (101085423), dog CPSF4 (489859), chicken CPSF4 (416494), Zebrafish cpsf4 (30203), cow CPSF4 (280875), naked mole-rat Cpsf4 (101698559)
UniProtKB ID:
O95639, D6W5S8, Q6FGE6, Q86TF8, Q9BTW6
Gene ID:
  • Human(10898) Summary: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(54188) cleavage and polyadenylation specific factor 4
  • Rat(304277) cleavage and polyadenylation specific factor 4
  • domestic guinea pig(100722077) cleavage and polyadenylation specific factor 4, 30kDa
  • domestic cat(101085423) cleavage and polyadenylation specific factor 4, 30kDa
  • dog(489859) cleavage and polyadenylation specific factor 4, 30kDa
  • chicken(416494) cleavage and polyadenylation specific factor 4, 30kDa
  • Zebrafish(30203) cleavage and polyadenylation specific factor 4
  • cow(280875) cleavage and polyadenylation specific factor 4, 30kDa
  • naked mole-rat(101698559) cleavage and polyadenylation specific factor 4, 30kDa

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