ASCC1
activating signal cointegrator 1 complex subunit 1
Synonyms:
ASC1p50, p50
Species:
Human ASCC1 (51008), Mouse Ascc1 (69090), Rat Ascc1 (294512), Zebrafish ascc1 (550273), chicken ASCC1 (423709), cow ASCC1 (534915), naked mole-rat Ascc1 (101726495), domestic cat ASCC1 (101081081), dog ASCC1 (608331), sheep ASCC1 (101113387)
UniProtKB ID:
Gene ID:
- Human(51008) Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Mouse(69090) activating signal cointegrator 1 complex subunit 1
- Rat(294512) activating signal cointegrator 1 complex subunit 1
- Zebrafish(550273) activating signal cointegrator 1 complex subunit 1
- chicken(423709) activating signal cointegrator 1 complex subunit 1
- cow(534915) activating signal cointegrator 1 complex subunit 1
- naked mole-rat(101726495) activating signal cointegrator 1 complex subunit 1
- domestic cat(101081081) activating signal cointegrator 1 complex subunit 1
- dog(608331) activating signal cointegrator 1 complex subunit 1
- sheep(101113387) activating signal cointegrator 1 complex subunit 1
- Goat(100861081) activating signal cointegrator 1 complex subunit 1
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