α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
C8982
α-Cyano-4-hydroxycinnamic acid
suitable for MALDI-TOF MS
Synonym(s):
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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About This Item
Linear Formula:
HOC6H4CH=C(CN)CO2H
CAS Number:
Molecular Weight:
189.17
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Form:
powder
Quality level:
Pricing and availability is not currently available.
form
powder
Quality Level
analyte chemical class(es)
glycans, peptides, proteins
mp
245-250 °C (lit.)
suitability
suitable for MALDI-TOF MS
storage temp.
room temp
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
General description
α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.[1]
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
Application
α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
ProteoMass is a trademark of Sigma-Aldrich Co. LLC
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This Item | |||
|---|---|---|---|
| form powder | form solid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| mp 245-250 °C (lit.) | mp 245-250 °C | mp 245-250 °C | mp 245-250 °C (lit.) |
| suitability suitable for MALDI-TOF MS | suitability - | suitability - | suitability - |
| analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) - |
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1B
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8982-10MG | 04061832011288 |
| C8982-10X10MG | 04061835572359 |
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What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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