Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

C2211

Sigma-Aldrich

Z-Leu-Leu-Leu-al

≥90% (HPLC)

Synonym(s):

MG-132

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
133407-82-6
Molecular Weight:
475.62
MDL number:
MFCD00674886
UNSPSC Code:
12352209
PubChem Substance ID:
24892475
NACRES:
NA.32
Pricing and availability is not currently available.

Product Name

Z-Leu-Leu-Leu-al, ≥90% (HPLC)

Quality Level

200

Assay

≥90% (HPLC)

form

powder

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

Gene Information

human ... CTSB(1508) , NFKB1(4790) , PSMA1(5682)

Looking for similar products? Visit Product Comparison Guide

Amino Acid Sequence

Z-Leu-Leu-Leu-al

Application

Z-Leu-Leu-Leu-al or MG132 has been used as a proteasome inhibitor.[1][2] It has also been used to test the ubiquitylation and sumoylation pathways in urchin embryos.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000403998
0000403998
0000350079
0000279057
0000257360

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

MG132, a proteasome inhibitor, induced death of calf pulmonary artery endothelial cells via caspase-dependent apoptosis and GSH depletion.
Anticancer Research (2010)
Vaino K. Hopsu-Havu, Mikko Jarvinen, Heidrun Kirschke
Proteolysis in Cell Functions (1997)
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain
Benjamin W
Journal of Neurochemistry (2016)
Proteasome inhibitors: from research tools to drug candidates
Alexei F.Kisselev
Chemistry and Biology, 8(8), 739-758 (2001)
An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client*
Johannes W. Bigenzahn
Molecular and Cellular Proteomics (2016)
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How should Product C2211, Z-Leu-Leu-Leu-al, be dissolved?

    1 answer

    1. MG132 is soluble in DMSO or at 10 mg/mL in a chloroform:methanol solution (95:5). We test the solubility at 1 mg/mL in methanol.

      Helpful?

  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  3. What is the solution stability of MG132, Product C2211, Z-Leu-Leu-Leu-al?

    1 answer

    1. This product can be stored in aliquots at -20°C for up to one month.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service