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N-Acetyl-Asp-Glu-Val-Asp-al

Name: N-Acetyl-Asp-Glu-Val-Asp-al
Brand: SIGMA

≥95%, powder

Synonym(s):

Ac-DEVD-CHO

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₀N₄O₁₁

CAS Number:

169332-60-9

Molecular Weight:

502.47

NACRES:

NA.32

PubChem Substance ID:

24890193

UNSPSC Code:

12352209

MDL number:

MFCD00671412

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Properties

biological source

synthetic

Quality Segment

100

assay

≥95%

form

powder

color

white

solubility

H₂O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

Description

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.[1]

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples,[2] smooth muscle cells[3] and Jurkat T-cells.[4]

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.[1]

Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

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This Item	A6339	A2559	A1086
Sigma-Aldrich A0835 N-Acetyl-Asp-Glu-Val-Asp-al	Sigma-Aldrich A6339 N-Acetyl-Val-Glu-Ile-Asp-al	Sigma-Aldrich A2559 N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide	Sigma-Aldrich A1086 N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin
assay ≥95%	assay ~99% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)
biological source synthetic	biological source -	biological source -	biological source -
Gene Information human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)	Gene Information human ... CASP6(839)	Gene Information human ... CASP3(836)	Gene Information -
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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