Skip to Content
Merck
All Photos(1)

Documents

320M-1

Sigma-Aldrich

Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

clone Ks20.8, unconjugated, Cell Marque™

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Ks20.8, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (320M-14)
vial of 0.5 mL concentrate (320M-15)
bottle of 1.0 mL predilute (320M-17)
vial of 1.0 mL concentrate (320M-16)
bottle of 7.0 mL predilute (320M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:500

isotype

IgG2aκ

control

colon carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT20(54474)

General description

Cytokeratin 20 is a 46-kDa intermediate filament protein that reacts primarily with gastricand intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is usefulin the identification of specific types of these epithelial cells under normal, hyperplastic,and neoplastic conditions. Cytokeratin 20 has been detected in various adenocarcinomas,including those of the colon and stomach. Merkel cell carcinomas have shown reactivity. Incontrast, carcinomas of the breast are generally non-reactive.

Quality


IVD
IVD
IVD
RUO

Linkage

Cytokeratin 20 Positive Control Slides , Product No. 320S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

T Tot
Cancer, 85(1), 171-177 (1999-01-28)
Metastatic adenocarcinoma in the liver with an unidentified primary tumor site is a common clinical problem. Pathologists often are asked to identify the primary tumor site. The histologic picture itself usually is not helpful, because the histology may be similar
Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas
Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM
Appl. Immunohistochem., 3, 99-107 (1995)
T Tot
Cancer, 92(10), 2727-2732 (2001-12-18)
Immunohistochemistry is a useful method in the differential diagnosis between pleural mesotheliomas and metastatic adenocarcinomas to the pleura. Cytokeratin (CK) 5-6 is one of the most specific mesothelioma-associated antibodies. Cytokeratin 20 and CK7 have been used successfully in studies determining
A Rullier et al.
The American journal of surgical pathology, 24(6), 870-876 (2000-06-08)
In the liver, the immunostaining of cytokeratins (CK) 7 and 20 has been used to distinguish usual peripheral cholangiocarcinomas (CC) and colorectal carcinoma metastasis (CRM). However, other subtypes of CC are not infrequent and may be particularly difficult to distinguish
R Moll et al.
The Journal of cell biology, 111(2), 567-580 (1990-08-01)
A major cytoskeletal polypeptide (Mr approximately 46,000; protein IT) of human intestinal epithelium was characterized by biochemical and immunological methods. The polypeptide, which was identified as a specific and genuine mRNA product by translation in vitro, reacted, in immunoblotting after
View All Related Papers

Articles

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

Related Content

Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Diagnostic Immunohistochemistry Procedures

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service