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377074

Sigma-Aldrich

Pentafluorophenyl trifluoroacetate

98%, for peptide synthesis

Synonym(s):

Trifluoroacetic acid pentafluorophenyl ester

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About This Item

Linear Formula:
CF3CO2C6F5
CAS Number:
14533-84-7
Molecular Weight:
280.07
Beilstein:
2003848
MDL number:
MFCD00134438
UNSPSC Code:
12352101
PubChem Substance ID:
24863490
NACRES:
NA.22

product name

Pentafluorophenyl trifluoroacetate, 98%

Quality Level

200

Assay

98%

form

liquid

refractive index

n20/D 1.368 (lit.)

bp

122-123 °C (lit.)

density

1.63 g/mL at 25 °C (lit.)

application(s)

peptide synthesis

SMILES string

Fc1c(F)c(F)c(OC(=O)C(F)(F)F)c(F)c1F

InChI

1S/C8F8O2/c9-1-2(10)4(12)6(5(13)3(1)11)18-7(17)8(14,15)16

InChI key

VCQURUZYYSOUHP-UHFFFAOYSA-N

Application

Pentafluorophenyl trifluoroacetate can be used:
  • In the esterification of 2′-carboxyrhodamine dye to form pentafluorophenyl ester as a single isomer.
  • As an acylating agent and a coupling agent for the peptide-type coupling of N-substituted glycine oligomers.
  • In the synthesis of pentafluorophenyl thiophene-3-acetate (PFPTA) by reacting with 3-thiopheneacetic acid.

Other Notes

may contain a small amount of pentafluorophenol

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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