124087

2-Bromo-4-methylaniline

98%

• Synonym(s): 2-Bromo-p-toluidine, 4-Amino-3-bromotoluene
• Linear Formula: BrC₆H₃(CH₃)NH₂
• CAS Number: 583-68-6
• Molecular Weight: 186.05
• Beilstein: 1931711
• EC Number: 209-515-7
• MDL number: MFCD00007635
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847595
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• form: liquid
• refractive index: n20/D 1.602 (lit.)
• bp: 240 °C (lit.)
• mp: 14-16 °C (lit.)
• density: 1.5 g/mL at 25 °C (lit.)
• SMILES string: Cc1ccc(N)c(Br)c1
• InChI: 1S/C7H8BrN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3
• InChI key: UVRRJILIXQAAFK-UHFFFAOYSA-N

Description

General description

2-Bromo-4-methylaniline participates in palladium catalyzed selective amination of 3-bromoquinoline to yield 3-(2-bromo-4-methylphenylamino) quinoline. It reacts with ethyl and methyl imidazo[1,2-a]pyridine-2-carboxylates in the presence of Me₃Al to form amide.

Application

2-Bromo-4-methylaniline has been used in the synthesis of iminophosphoranes.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves