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USP

Butoconazole nitrate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole mononitrate

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About This Item

Empirical Formula (Hill Notation):
C19H17Cl3N2S · HNO3
CAS Number:
64872-77-1
Molecular Weight:
474.79
MDL number:
MFCD00058159
UNSPSC Code:
41116107
PubChem Substance ID:
329749174
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

butoconazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O

InChI

1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

InChI key

ZHPWRQIPPNZNML-UHFFFAOYSA-N

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General description

Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.

Application

Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
A Nikolov et al.
Akusherstvo i ginekologiia, 46(9), 23-26 (2008-07-23)
To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy. 28 pregnant women in third trimester with recurrent vaginal Candida infection were included in the study. All cases were treated
D Brown et al.
The Journal of reproductive medicine, 44(11), 933-938 (1999-12-10)
To compare the safety and efficacy of a single vaginal dose of a butoconazole nitrate 2% bioadhesive, sustained-release cream* (butoconazole 1-BSR) with a seven-day schedule of miconazole nitrate vaginal cream 2% (miconazole 7). The clinical trial was conducted according to
E Rachev
Akusherstvo i ginekologiia, 46(2), 25-27 (2007-05-02)
to have a personal experience concerning the therapeutic characteristics of the new product GYNAZOL (Gedeon Richter, Ltd)--5 g. vaginal cream for treatment of vulvo-vaginal candidosis (VVC). 31 women in reproductive and climacteric age suffering from acute or chronic VVC. inquiry
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