T9177
Tyrphostin AG 126
≥90%
Synonym(s):
(3-Hydroxy-4-nitrobenzylidene)malononitrile
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About This Item
Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
Molecular Weight:
215.17
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥90%
storage temp.
−20°C
SMILES string
Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N
Gene Information
human ... TNF(7124)
Application
Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.
Biochem/physiol Actions
Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Oliver Kann et al.
Journal of neurochemistry, 90(3), 513-525 (2004-07-17)
We recently reported that lasting activation of mouse microglial cells with bacterial lipopolysaccharide (LPS) chronically elevated the basal intracellular calcium concentration ([Ca2+]i). This correlated to an attenuated calcium signaling of complement (C5a) and purinergic (UTP) receptors as well as to
Yong-ming Yao et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 42(7), 391-395 (2004-05-18)
To investigate the effects of extracellular signal-regulated kinase (ERKs) inhibition by AG126 on tissue tumor necrosis factor-alpha (TNF-alpha) expression and multiple organ dysfunction in rats with postburn Staphylococcus aureus sepsis and its potential signal regulating mechanism. To reproduce postburn sepsis
Kyril Turpaev et al.
Biochemical pharmacology, 82(5), 535-547 (2011-06-15)
Benzylidenemalononitrile (BMN) tyrphostins are well known as potent tyrosine kinase inhibitors. Moreover, in recent years it has been recognized that members of the tyrphostin family possess additional biological activities independent of their ability to inhibit protein tyrosine kinases. In this
J Michelle Kahlenberg et al.
Journal of leukocyte biology, 76(3), 676-684 (2004-07-09)
The release of IL-1beta as an active, mature cytokine requires proteolytic processing by caspase-1, which is recruited to signaling complexes that facilitate its autocatalytic proteolysis and activation. Caspase-1 processing has been characterized in human monocyte and murine macrophage model systems
S Cuzzocrea et al.
Laboratory investigation; a journal of technical methods and pathology, 80(9), 1439-1453 (2000-09-27)
Inflammatory bowel disease is characterized by oxidative and nitrosative stress, leukocyte infiltration, up-regulation of the expression of intercellular adhesion molecule-1 (ICAM-1), and up-regulation of P-selectin in the colon. Here we investigate the effects of the tyrosine kinase inhibitor, Tyrphostin AG
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