T6277
Monoclonal Anti-Troponin T antibody produced in mouse
clone JLT-12, ascites fluid
Synonym(s):
Anti-ANM, Anti-NEM5, Anti-STNT, Anti-TNT, Anti-TNTS
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About This Item
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biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
JLT-12, monoclonal
contains
15 mM sodium azide
species reactivity
chicken, rat, bovine, rabbit
technique(s)
immunohistochemistry: suitable
western blot: 1:200 using rabbit total skeletal muscle extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Tnnt1(171409) , Tnnt2(24837) , Tnnt3(24838)
Related Categories
General description
Monoclonal Anti-Troponin T (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Troponin T is a vital subunit of troponin. Troponin T is a comma or rod shaped protein with a length of 185-205 Å. Troponin T is positioned in the actin helix groove and is extended along the filament of troponin. Life span of serum troponin T is 120 minutes. N- terminal end of the protein is enriched in negatively charged residues and C- terminal end is enriched with positively charged residues. This uneven distribution of charges in troponin T facilitates its aggregation at physiological salt concentration. In humans, cardiac troponin T exists in four isoforms, out of which three are expressed in the fetus and one isoform is expressed in the adult heart.
Immunogen
Troponin T from rabbit skeletal muscle.
Application
Monoclonal Anti-Troponin T antibody produced in mouse has been used in following studies:
- Western blot analysis.
- Immunocytochemical analysis.
- Immunofluorescence.
Monoclonal Anti-Troponin T antibody produced in mouse has been used in immunostaining.
Biochem/physiol Actions
Troponin T is a subunit of troponin, which facilitates binding of troponin to tropomyosin. It also plays a crucial role in muscle contraction. Cardiac troponin T acts as a potential marker for the detection of acute myocardial infarction (MI). Apart from facilitating binding of troponin components to the actin-tropomyosin filament, it is has an essential role in the regulation of actomyosin ATPase activity. Cardiac troponin T gene mutation leads to hypertrophic cardiomyopathy.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The present study was designed to evaluate the efficiency of a newly developed troponin T enzyme immunoassay for the detection of acute myocardial infarction. The study comprised 388 patients admitted with chest pain and suspected myocardial infarction and 101 patients
V L Filatov et al.
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Journal of the American College of Cardiology, 29(3), 549-555 (1997-03-01)
This study was designed to verify initial observations of the clinical and prognostic features of hypertrophic cardiomyopathy caused by cardiac tropnin T gene mutations. The most common cause of sudden cardiac death in the young is hypertrophic cardiomyopathy, which is
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