SRP6312
Alpha 1 Antitrypsin from human plasma
HBsAg, HCV, HBc free, ≥95% (SDS-PAGE)
Synonym(s):
AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, PI, Serpin A1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
human
Assay
≥95% (SDS-PAGE)
form
lyophilized
potency
≥5.0 I.U. per mg
mol wt
52 kDa
packaging
pkg of 1 mg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... Serpin A1(5265)
General description
Our Alpha 1 Antitrypsin is a human plasma protein.It is shown to be HBsAg, HCV, HBc free and also negative for anti HIV1 and HIV2 according to FDA approved tests.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1. AAT is an acute-phase plasma protein. It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells. AAT is also referred to as Serpin A1.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1. AAT is an acute-phase plasma protein. It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells. AAT is also referred to as Serpin A1.
Application
AAT (α 1 antitrypsin) from human plasma has been used as a standard to check the presence of AAT in benign and malignant lymphoreticular cells and tissues.
Biochem/physiol Actions
AAT (α 1 antitrypsin) functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of AAT and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in AAT occurs as an acute phase response to tissue necrosis and inflammation. It might work as a biomarker for cutaneous squamous cell carcinoma, hepatitis B, insulinomas, NSCLC (non-small cell lung cancer), papillary thyroid carcinoma, lung cancer and breast carcinoma.
Physical form
Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
Reconstitution
In water or aqueous buffer
Storage Class Code
13 - Non Combustible Solids
WGK
nwg
Certificates of Analysis (COA)
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Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.
Schaefer B
Human Molecular Genetics, 24, 6254-6263 (2015)
Alpha 1 antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z. A survey by the British Thoracic Association.
Tobin MJ
British Journal of Diseases of the Chest, 77, 14-27 (1983)
SERPINA2 is a novel gene with a divergent function from SERPINA1.
Marques PI
PLoS ONE, 8, e66889-e66889 (2013)
Alpha1-antitrypsin and alpha2-macroglobulin. Interactions with human neutrophil collagenase and elastase.
Ohlsson K
Annals of the New York Academy of Sciences, 256, 409-419 (1975)
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
Carrell RW
The Journal of Clinical Investigation, 78, 1427-1431 (1986)
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