SML3644
JR-AB2-011
≥98% (HPLC)
Synonym(s):
3-(3,4-Dichlorophenyl)-1-(4-fluorophenyl)-1-(5-methyl-4,5-dihydrothiazol-2-yl)urea, N-(3,4-Dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-3-thiazolidinecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C17H14Cl2FN3OS
CAS Number:
Molecular Weight:
398.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Biochem/physiol Actions
JR-AB2-011 is a selective mTORC2 inhibitor that blocks the interaction of Rictor and mTOR (IC50 = 0.31 µM) without affecing mTORC1 activity or assembly. JR-AB2-011 exhibits anti-glioblastoma (GBM) activity in vitro (proliferation IC50 = 0.31 µM post 72h treatment, 36.3% apoptosis post 48h 1 µM treatment in LN229 cultures) and in vivo (4 or 20 mg/kg/d i.p. to LN229 xenografted mice).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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