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SML2795

Sigma-Aldrich

IMP-1700

≥98% (HPLC)

Synonym(s):

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid, 1-Cyclopropyl-6-fluoro-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C25H22F4N4O3S
CAS Number:
1458674-25-3
Molecular Weight:
534.53
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C1=CN(C2CC2)C(C=C(N3CCN(C(NC4=CC=C(C=C4)C(F)(F)F)=S)CC3)C(F)=C5)=C5C1=O)=O

Biochem/physiol Actions

IMP-1700 is a cell-active and potent inhibitor of bacterial DNA repair that inhibits the bacterial SOS-response to DNA damage. IMP-1700 targets AddAB/RecBCD repair complex and potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carine S Q Lim et al.
Bioorganic & medicinal chemistry, 27(20), 114962-114962 (2019-07-17)
The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore

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