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SML1042

Sigma-Aldrich

Eptifibatide acetate

≥98% (HPLC)

Synonym(s):

Cyclo(S,S)-Mpr(Har)GDWPC-NH2 acetate, N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide cyclic (16)-disulfide acetate

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About This Item

Empirical Formula (Hill Notation):
C35H49N11O9S2 · xC2H4O2
CAS Number:
881997-86-0
Molecular Weight:
831.96 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

General description

Eptifibatide acetate is a cyclic heptapeptide. It is the member of the class arginin-glycin-aspartat-mimetics. Eptifibatide has a short half-life. The drug decreases the risk of myocardial infarction (MI). Eptifibatide acetate might be associated with thrombocytopenia.

Biochem/physiol Actions

Eptifibatide is a specific inhibitor of fibrinogen binding to the platelet membrane integrin glycoprotein GPIIb/IIIa receptor, preventing platelet aggregation. Eptifibatide binds reversibly and competitively.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rousan TA, et al.
American Journal of Hematology, 85(1), 71-74 (2010)
Clinical review: traumatic brain injury in patients receiving antiplatelet medication
Beynon C, et al.
Critical Care, 16(4), 228-228 (2012)
Eptifibatide: A cyclic peptide that selectively inhibits platelet glycoprotein IIb/IIIa
Heras M and Escolar G
Drugs Today (Barc), 36, 295-311 (2000)
Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
Bhatt DL and Topol EJ
JAMA : The Journal of the American Medical Association, 284(12), 1549-1558 (2000)
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Toxicon : official journal of the International Society on Toxinology, 159, 50-60 (2019-01-25)
Victims of Bothrops jararaca snakebites manifest bleedings, blood incoagulability, platelet dysfunction, and thrombocytopenia, and the latter has been directly implicated in the genesis of hemorrhagic diathesis. We addressed herein the direct effects of B. jararaca venom (BjV) on ex vivo

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