SAB5701913

Anti-Phospho-CRK/CRKII-Y221 antibody produced in rabbit

• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: monoclonal
• form: liquid
• species reactivity: rat, human
• concentration: 0.53 mg/mL
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P46108
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr221)
• Gene Information: human ... CRK(1398)

Description

General description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Immunogen

A phospho specific peptide corresponding to residues surrounding Y221 of human CRK/CRKII

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable