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SAB4501587

Sigma-Aldrich

Anti-Integrin beta 3 (ITGB3/CD61) Antibody

rabbit polyclonal

Synonym(s):

CD61, GP3A, GPIIIa, ITB3, integrin β-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

Product Name

Anti-Integrin β3 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 87 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P05106

UniProt accession no.

P05106

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGB3(3690)

General description

Anti-Integrin β3 Antibody detects endogenous levels of total Integrin β3 protein.

ITGB3 (integrin subunit β 3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.

Immunogen

The antiserum was produced against synthesized peptide derived from human Integrin beta3.

Immunogen Range: 739-788

Biochem/physiol Actions

Mutations in ITGB3 (integrin subunit β 3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells promoted by reactive oxygen species.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
217119

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Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells
Lei Y, et al.
Molecular and Cellular Proteomics, 10(10) (2011)
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models
Nurden AT, et al.
Blood, 118(23), 5996-6005 (2011)
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Ghevaert C, et al.
Blood, 111(7), 3407-3414 (2008)

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