SAB4300151

Anti-phospho-EGFR (pThr⁶⁷⁸) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-ERBB antibody produced in rabbit, Anti-ERBB1 antibody produced in rabbit, Anti-HER1 antibody produced in rabbit, Anti-PIG61 antibody produced in rabbit, Anti-epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~175 kDa
• species reactivity: mouse, human, rat
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (K-R-TP-L-R)
• NCBI accession no.: NP_005219.2
• UniProt accession no.: P00533
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr678)
• Gene Information: human ... EGFR(1956)

Description

Immunogen

Peptide sequence around phosphorylation site of threonine 678 (K-R-T(p)-L-R), according to the protein EGFR.

Features and Benefits

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Target description

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable