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P0048

Sigma-Aldrich

Pemoline

≥98% (HPLC)

Synonym(s):

2-Amino-5-phenyl4(5H)-oxazolone, Phenylisohydantoin

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About This Item

Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
2152-34-3
Molecular Weight:
176.17
EC Number:
218-438-8
MDL number:
MFCD00083197
UNSPSC Code:
12352200
PubChem Substance ID:
329819998
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.2; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

solubility

DMSO: 28 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(O1)c2ccccc2

InChI

1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

InChI key

NRNCYVBFPDDJNE-UHFFFAOYSA-N

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Biochem/physiol Actions

Pemoline is a CNS stimulant. Pemoline is used to treat attention-deficit hyperactivity disorder (ADHD). Pemoline is a Schedule IV drug and offers some advantages over other stimulants in that it does not reduce the appetite or cause dry mouth.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Darragh P Devine
Methods in molecular biology (Clifton, N.J.), 829, 65-84 (2012-01-11)
Self-injurious behaviour is highly prevalent in neurodevelopmental disorders. Interestingly, it is not restricted to any individual diagnostic group. Rather, it is exhibited in various forms across patient groups with distinct genetic defects and classifications of disorders. This suggests that there
Nina Oestreicher et al.
Pharmacoepidemiology and drug safety, 16(12), 1268-1272 (2007-11-28)
A recent report linked methylphenidate (MPH) use in children to cytologic abnormalities in plasma lymphocytes, a possible cancer biomarker. The purpose of this study was to investigate the association of MPH use and childhood cancer risk. Using automated pharmacy databases
Amber M Muehlmann et al.
Behavioural brain research, 217(1), 148-154 (2010-10-27)
Self-injurious behavior (SIB) is a debilitating characteristic that is prevalent across a broad spectrum of neurodevelopmental disorders. In most of these disorders, some individuals exhibit SIB, whereas others do not. However, the neurobiological mechanisms that confer vulnerability are virtually unexplored.
Christopher M Bloom et al.
Crisis, 33(2), 106-112 (2012-02-22)
Historically, the field of self-injury has distinguished between the behaviors exhibited among individuals with a developmental disability (self-injurious behaviors; SIB) and those present within a normative population (nonsuicidal self-injury; NSSI),which typically result as a response to perceived stress. More recently
Scott P Novak et al.
Substance abuse treatment, prevention, and policy, 2, 32-32 (2007-11-02)
Emerging evidence suggests that nonmedical use (NMU) of prescription attention deficit/hyperactivity disorder (ADHD) medications is rising, but many previous investigations have used clinical or regionally based samples or limited their investigations to stimulants rather than to medications specifically used to
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