N6664

Neurodazine

≥98% (HPLC)

• Synonym(s): 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H imidazole
• Empirical Formula (Hill Notation): C₂₇H₂₁ClN₂O₃
• CAS Number: 937807-66-4
• Molecular Weight: 456.92
• MDL number: MFCD08906055
• UNSPSC Code: 12352203
• PubChem Substance ID: 329818668
• NACRES: NA.25

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: >20 mg/mL
• storage temp.: −20°C
• SMILES string: COc1ccc(cc1)-c2nc([nH]c2-c3ccc(OC)cc3)-c4ccc(o4)-c5cccc(Cl)c5
• InChI: 1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)
• InChI key: FEEOFPAEDSMOTO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H318,H413
• Precautionary Statements: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Dam. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves