As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.
M4263
Malonyl coenzyme A lithium salt
≥90% (HPLC)
Synonym(s):
Malonyl CoA lithium salt
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About This Item
Empirical Formula (Hill Notation):
C24H38N7O19P3S · xLi+
CAS Number:
Molecular Weight:
853.58 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Pricing and availability is not currently available.
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Quality Level
Assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble 50 mg/mL protein, clear, colorless
storage temp.
−20°C
SMILES string
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
InChI
1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
InChI key
OPIJLICRFQMMJH-UHFFFAOYSA-N
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Application
Malonyl coenzyme A lithium salt has been used:
- in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
- in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase[2]
- as an internal standard in the reaction mixture used for succinyl-CoA ligase assay[3]
Biochem/physiol Actions
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.[4]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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R G Summers et al.
Biochemistry, 34(29), 9389-9402 (1995-07-25)
Streptomyces glaucescens, a Gram-positive soil bacterium, produces the polyketide antibiotic tetracenomycin (Tcm) C. To study possible biochemical connections between the biosynthesis of bacterial fatty acids and polyketides, the abundant acyl carrier protein (ACP) detected throughout the growth of the tetracenomycin
J Kalervo Hiltunen et al.
Biochimica et biophysica acta, 1797(6-7), 1195-1202 (2010-03-17)
Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through
Gary D Lopaschuk et al.
Pharmacological reviews, 62(2), 237-264 (2010-04-16)
The central nervous system mediates energy balance (energy intake and energy expenditure) in the body; the hypothalamus has a key role in this process. Recent evidence has demonstrated an important role for hypothalamic malonyl CoA in mediating energy balance. Malonyl
Principles of diabetes mellitus, 96-96 (2010)
Establishing a reference interval for measurement of flux through the mitochondrial fatty acid oxidation pathway in cultured skin fibroblasts.
Srinivas B Narayan et al.
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whats the appropriate solvent? PBS? DMSO? DW?
1 answer-
Helpful?
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Malonyl Coenzyme A can be store as aqueous solution ?
1 answer-
The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.
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