M3316

Myoseverin B

≥97% (HPLC)

• Synonym(s): 2,6-Bis(4-methoxybenzylamino)-9-cyclohexylpurine
• Empirical Formula (Hill Notation): C₂₇H₃₂N₆O₂
• CAS Number: 361431-27-8
• Molecular Weight: 472.58
• MDL number: MFCD08276922
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724538
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• solubility: DMSO: soluble; H₂O: insoluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c4ncn(C5CCCCC5)c4n2)cc1
• InChI: 1S/C27H32N6O2/c1-34-22-12-8-19(9-13-22)16-28-25-24-26(33(18-30-24)21-6-4-3-5-7-21)32-27(31-25)29-17-20-10-14-23(35-2)15-11-20/h8-15,18,21H,3-7,16-17H2,1-2H3,(H2,28,29,31,32)
• InChI key: ZUZXYJOSNSTJMU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Myoseverin, a new microtubule-binding molecule, acts reversibly on myoblast proliferation without the cytotoxic effects displayed by nonpurine-based microtubule-disrupting molecules, like taxol, vinblastine, nocodazole. Myoseverin can be effectively used for the inhibition of new vessel growth by inhibiting endothelial cell function and differentiation of progenitor cells.

Tubulin polymerization inhibitor.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves