J4705
Jatrorrhizine
from Tinospora sagittata, ≥95% (HPLC)
Synonym(s):
7,8,13,13α-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium, Neprotin, Yatrorizine
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biological source
Tinospora sagittata
Assay
≥95% (HPLC)
storage temp.
2-8°C
InChI
1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
InChI key
MXTLAHSTUOXGQF-UHFFFAOYSA-O
Biochem/physiol Actions
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Potential therapeutic for gastrointestinal disorders.
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Mayurkumar B Patel et al.
Phytotherapy research : PTR, 26(9), 1342-1347 (2012-02-02)
The inhibitory activity of Tinospora cordifolia stem-derived alkaloids was evaluated against lens aldose reductase (AR) isolated from male Wistar rats. Anticataract potential of the alkaloids of T. cordifolia was evaluated in vitro in rat lenses, considering the activity of normal
Gang Fan et al.
Analytica chimica acta, 747, 76-83 (2012-09-19)
Rhizoma coptidis, a broadly used traditional Chinese medicine, derives from the dried rhizomes of Coptis chinensis Franch, Coptis deltoidea C.Y. Cheng et Hsiao and Coptis teeta Wall. Quantitative determination of protoberberine alkaloids in R. coptidis is critical for controlling its
Hao Wu et al.
Talanta, 85(1), 787-793 (2011-06-08)
The fluorescence spectra of berberine, palmatine, jatrorrhizine, and coptisine in ionic liquids were studied and found to increase significantly in ionic liquids, with [C(8)MIM][PF(6)] having the greatest increase. Further studies showed that these drugs could be extracted from an aqueous
Jin Feng et al.
Journal of pharmaceutical and biomedical analysis, 53(3), 591-598 (2010-05-01)
A sensitive, rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in scutellaria-coptis herb couple in rat plasma. After protein precipitation with acetonitrile and
Lihong Liu et al.
Analytica chimica acta, 737, 99-104 (2012-07-10)
A sensitive and precise high performance liquid chromatography (HPLC)-electrochemical detection (ECD) method has been developed for the simultaneous determination of four isoquinoline alkaloids including berberine, jatrorrhizine, coptisine and palmatine in Chinese medicine Coptis chinensis. The typical HPLC analysis was performed
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