I8657
Interferon α from rat
≥95%, recombinant, expressed in bacteria, lyophilized powder, suitable for cell culture
Synonym(s):
IFN-α
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About This Item
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biological source
rat
Quality Level
recombinant
expressed in bacteria
Assay
≥95%
form
lyophilized powder
mol wt
~19 kDa
packaging
pkg of 1 vial
concentration
300,000-800,000,000 units/mL
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
rat ... Ifna_mapped(24480)
General description
Biochem/physiol Actions
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
Interferon α play a key role in the inhibition of in vitro proliferation of hematopoietic progenitors.[2] It mediates the regulation of gene expression that is responsible for development and functionality of innate and adaptive immunity.[3] It has been used as myelosuppressive agent for myeloproliferative neoplasms (MPNs).[2]
Physical form
Lyophilized from a solution containing citric acid buffered saline (CBS pH 5.0) and 125 mM trehalose
Analysis Note
The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV) in the presence of 2mM glutathione. The cytopathic effect of 50% is produced with ~1 unit/mL interferon. Since there is no international rat interferon α standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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The interferon system of teleost fish
Robertsen B
Fish & Shellfish Immunology, 20(2), 172-191 (2006)
Agnieszka Rynda et al.
PloS one, 5(1), e8720-e8720 (2010-01-22)
Conventional methods to induce tolerance in humans have met with limited success. Hence, efforts to redirect tolerogen uptake using reovirus adhesin, protein sigma 1 (psigma1), may circumvent these shortcomings based upon the recent finding that when reovirus psigma1 is engineered
Jie-Hyun Kim et al.
Yonsei medical journal, 47(6), 793-798 (2006-12-28)
Combination therapy with interferon alpha (IFN-alpha) and ribavirin for 24 or 48 weeks according to HCV genotype has improved the overall sustained virological response (SVR) rates to approximately 40%. The aim of this study was to investigate the long-term efficacy
Type I interferons (?/?) in immunity and autoimmunity
Theofilopoulos AN, et al.
Fish & Shellfish Immunology, 23(11), 307-335 (2005)
Interferon- ? therapy in bcr-abl-negative myeloproliferative neoplasms
Kiladjian JJ, et al.
Leukemia, 22(11), 1990-1990 (2008)
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