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Key Documents

H9279

Sigma-Aldrich

α-Hydroxyfarnesylphosphonic acid

2 mg/mL in ethanol

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About This Item

Empirical Formula (Hill Notation):
C15H27O4P
CAS Number:
Molecular Weight:
302.35
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

concentration

2 mg/mL in ethanol

storage temp.

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\C(O)P(O)(O)=O

Biochem/physiol Actions

Inhibitor of farnesyltransferase; much weaker activity against geranylgeranyl transferase.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

57.2 °F - closed cup - Solvent

Flash Point(C)

14.0 °C - closed cup - Solvent

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J B Gibbs et al.
The Journal of biological chemistry, 268(11), 7617-7620 (1993-04-15)
The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to be capable of transforming mammalian cells. Farnesylation appears to be a critical modification of Ras, and thus

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