C7934
2-Chloro-N6-cyclopentyl-1-deazaadenosine
Synonym(s):
DCCA
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About This Item
Empirical Formula (Hill Notation):
C16H21ClN4O4
CAS Number:
Molecular Weight:
368.82
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
SMILES string
OCC1OC(C(O)C1O)n2cnc3c(NC4CCCC4)cc(Cl)nc23
InChI
1S/C16H21ClN4O4/c17-11-5-9(19-8-3-1-2-4-8)12-15(20-11)21(7-18-12)16-14(24)13(23)10(6-22)25-16/h5,7-8,10,13-14,16,22-24H,1-4,6H2,(H,19,20)
InChI key
ZQSTWOIIMKNFPE-UHFFFAOYSA-N
Biochem/physiol Actions
A selective A1 adenosine receptor agonist
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nam D Nguyen et al.
PLoS computational biology, 16(4), e1007677-e1007677 (2020-04-03)
The molecular mechanisms and functions in complex biological systems currently remain elusive. Recent high-throughput techniques, such as next-generation sequencing, have generated a wide variety of multiomics datasets that enable the identification of biological functions and mechanisms via multiple facets. However
E A van Schaick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(6), 827-837 (1998-02-07)
In this study we investigated the relationship between the pharmacokinetics and the cardiovascular and electroencephalogram (EEG) effects of three adenosine agonists with differing lipophilicity. Conscious normotensive rats received either 600 microg/kg N6-(p-sulphophenyl) adenosine (SPA), 200 microg/kg N6-cyclopentyladenosine (CPA) or 600
Bin Yu et al.
BMC genomics, 19(1), 478-478 (2018-06-20)
Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. Apoptosis proteins subcellular localization information is very important for understanding the mechanism of programmed cell death and the development of drugs. Therefore, the
C Cano et al.
The Journal of pharmacology and experimental therapeutics, 261(2), 660-668 (1992-05-01)
The subtype of adenosine receptor linked to cardiac prostacyclin (PGI2) synthesis, measured as immunoreactive 6-keto-PGF1 alpha, was investigated in the rabbit heart perfused with Krebs' buffer at 20 ml/min. Adenosine (6.4-50 nmol) decreased 6-keto-PGF1 alpha synthesis, coronary perfusion pressure (PP)
Eduardo Pérez-Valera et al.
Scientific reports, 9(1), 6760-6760 (2019-05-03)
Bacterial genes responsible for resistance to antibiotic agents (ARG) are spread from livestock to soil through application of manure, threatening environmental and human health. We investigated the mechanisms of ARG dissemination and persistence to disentangle i) the influence of nutrients
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