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Sigma-Aldrich

Dextran from Leuconostoc spp.

Mr ~6,000

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About This Item

Linear Formula:
(C6H10O5)n
CAS Number:
9004-54-0
EC Number:
232-677-5
MDL number:
MFCD00130935
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

(Leuconostoc spp)

form

powder

mol wt

Mr ~6,000

color

white

mp

483  °C ((901 °F ))

solubility

water: 1.5 g/10 mL, colorless to faintly yellow

storage temp.

room temp

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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General description

Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 Kd. Dextrans are used in many applications as volume extenders, stabilizers, matrix components, binding platforms, lubricants and physical structure components. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their different viscosities, aggregation and permeation properties.
Dextran is an extracellular bacterial polymer of D-glucopyranose. It mostly comprises α-(1→6) linkage in the main chain and a variable number of α-(1→2), α-(1→3), α-(1→4) branched linkages.

Application

Dextran from Leuconostoc spp. has been used:
  • for the glycation of caseinate to investigate the influence of an increase in carbohydrate chain length compared to glucose
  • for the mass calibration of matrix-assisted laser desorption ionization-time of flight mass spectroscopy (MALDI-TOF) for the characterization of silver nanoparticles (AgNPs)
  • as a non-toxic stabilizer to assess the in vivo administration of tungsten trioxide(WO3) nanoparticles

Biochem/physiol Actions

Dextran is used as a drug, particularly as a blood plasma volume expander. It is also useful as an adjuvant, emulsifier, carrier, and stabilizer in the food, pharmaceutical, and chemical industries. Sephadex is a cross-linked dextran that is commonly used for the separation and purification of protein. In the food industry, dextran is applicable as a thickener for jam and ice cream. It hinders the crystallization of sugar and augments moisture retention. This preserves the flavor and appearance of several food items.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Thomas Rath et al.
Nephron. Clinical practice, 114(1), c81-c88 (2009-11-06)
Intravenous iron supplementation is a basic principle in the therapy of haemodialysis (HD) patients with renal anaemia. In the Iron Dextran in Renal Anaemia (IDIRA) study, we analysed the efficacy of a therapy with low-molecular-weight iron dextran (LMW-ID) in stable
R J Stenekes et al.
Biomaterials, 22(13), 1891-1898 (2001-06-09)
In this paper, a novel method is presented for the preparation of dextran hydrogels and microspheres, based on crystallization. Although dextrans are known to be well soluble in water, precipitation was observed in concentrated aqueous solutions of low molecular weight
Eugen Sisu et al.
Rapid communications in mass spectrometry : RCM, 20(2), 209-218 (2005-12-15)
A combined methodology for obtaining at the preparative scale and characterization by nanoelectrospray ionization (nanoESI) quadrupole time-of-flight (QTOF) mass spectrometry (MS) and tandem MS (MS/MS) of linear polysaccharides modified at the reducing end is presented. Two polydisperse maltodextrins (1000 and
Molecular Weight Effects on the Miscibility Behavior of Dextran and Maltodextrin with Poly(vinylpyrrolidone).
Van Eerdenbrugh B, Taylor LS.
Pharmaceut. Res., doi: 10-doi: 10 (2012)
Melda Altikatoglu et al.
Artificial cells, blood substitutes, and immobilization biotechnology, 40(4), 261-265 (2012-01-28)
In the present study, the stabilizing effect of dextrans as additives on the denaturation and inactivation of glucose oxidase (GOD) was investigated. Three different molecular weighted dextrans (M(w) 17.5, 75, 188 kD) were used with different concentrations. Dramatically increased enzyme
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