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CDUFBI001

Milli-Q

Biopak® Polisher

Ultrafilter for the production of pyrogen-, nuclease-, and bacteria-free water

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About This Item

UNSPSC Code:
41104212
eCl@ss:
33050190
NACRES:
NA.21
Pricing and availability is not currently available.

material

polysulfone (Ultrafiltration Hollow Fibers)

Quality Level

300

feature

removal of pyrogen (endotoxins), nuclease and bacteria in water

packaging

pkg of 1 unit

manufacturer/tradename

BioPak®

impurities

<0.001 EU/mL Pyrogens (endotoxins)
<0.01 ng/mL RNases
<0.1 cfu/mL Bacteria
<4 pg/μL DNases

compatibility

for use with Direct-Q® UV
for use with Direct-Q®
for use with Elix® Advantage
for use with Milli-Q® Direct
for use with Milli-Q® Reference
for use with Simplicity® UV
for use with Simplicity®
for use with Synergy® UV
for use with Synergy®

shipped in

ambient

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General description

The Biopak® Polisher is an ultrafiltration cartridge designed to produce water suitable for molecular biology, biochemistry and cell culture when fed with Milli-Q® purified water. It is validated for continuous use for 90 days.

Application

Biopak® Polisher is recommended for a wide range of laboratory applications such as molecular biology, cell culture and biochemistry, where bacteria, pyrogen and/or nuclease levels must be controlled. This includes bloodstream bacterial infections (BSIs) research,[1] electrochemical biosensor development,[2] endotoxin adsorption studies,[3] antimicrobial testing[4] and mRNA and protein detection.[5]

Features and Benefits

  • Minimizes risk of nuclease, pyrogen and bacteria contamination.
  • Eliminates the need for toxic agents such as DEPC, therefore improving safety, saving time and reducing costs.
  • Care-free maintenance: The polisher is easily installed and replaced; does not require sanitization.

Components

Ultrafiltation hollow fibers

Other Notes

Directions for Use

  • Organism Retention: Bacteria and pyrogens
  • Mode of Action: Ultrafiltration
  • Application: Cell culture media, molecular biology
  • Intended Use: Bioburden reduction
  • Instructions for Use: This item provides water filtered through ultrafiltration hollow fibers. Refer to insert, section "replacement" in the product package.
  • Storage Statement: Store in a dry location.
  • Disposal Statement: Dispose of in accordance with applicable federal, state and local regulations.

Legal Information

BIOPAK is a registered trademark of Merck KGaA, Darmstadt, Germany
DIRECT-Q is a registered trademark of Merck KGaA, Darmstadt, Germany
ELIX is a registered trademark of Merck KGaA, Darmstadt, Germany
Milli-Q is a registered trademark of Merck KGaA, Darmstadt, Germany
SIMPLICITY is a registered trademark of Merck KGaA, Darmstadt, Germany
SYNERGY is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Explicit measurement of the endotoxin adsorption efficiency detects non-Langmuir behavior at low concentrations
Kholina EG, et al.
Analytical biochemistry, 587, 113445-113445 (2019)
A Flowthrough Assay for Rapid Bedside Stratification of
Bloodstream Bacterial Infection in Critically Ill Patients: a Pilot
Study
Jagtap P, et al.
Journal of Clinical Microbiology, 56(9), e00408-e00418 (2018)
The importance of the assembling of DNA strands on the performance of electrochemical genosensors
Batistuti MR, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 159, 105358-105358 (2020)
FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry
Arrigucci R, et al.
Nature Protocols, 12(6), 1245-1260 (2017)
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain H, et al.
Scientific reports, 7(1), 1-11 (2017)

Articles

Water for Nuclease-sensitive Molecular Biology Studies

Nuclease-free water (or PCR water) is needed in molecular biology to avoid sample degradation during PCR, sequencing, etc. Ultrafiltration provides a quicker, safer, and more sustainable alternative to DEPC treatment when preparing RNase-free and DNase-free water.

Water for Nuclease-sensitive Molecular Biology Studies

Nuclease-free water (or PCR water) is needed in molecular biology to avoid sample degradation during PCR, sequencing, etc. Ultrafiltration provides a quicker, safer, and more sustainable alternative to DEPC treatment when preparing RNase-free and DNase-free water.

Water for Nuclease-sensitive Molecular Biology Studies

Nuclease-free water (or PCR water) is needed in molecular biology to avoid sample degradation during PCR, sequencing, etc. Ultrafiltration provides a quicker, safer, and more sustainable alternative to DEPC treatment when preparing RNase-free and DNase-free water.

Water for Nuclease-sensitive Molecular Biology Studies

Nuclease-free water (or PCR water) is needed in molecular biology to avoid sample degradation during PCR, sequencing, etc. Ultrafiltration provides a quicker, safer, and more sustainable alternative to DEPC treatment when preparing RNase-free and DNase-free water.

Questions

1–10 of 12 Questions  

  1. Please kindly advise how to dispose an used BioPak C Polisher

    1 answer

    1. Biopak® Cartridge is not classified in Europe as a hazardous substance in regard to the substance definition in Article 3 of the Regulation (EC) 1907/2006 of 18 December 2006 concerning the Registration, Evaluation, Authorization, and Restriction of Chemical (REACH) and in regards to the hazardous substance and mixtures classification criteria from the Annex I of the Regulation (EC) 1272/2008 of 16 December 2008 on classification, labeling and packaging of substance and mixtures.

      Biopak® Cartridge does not require in Europe any Safety Data Sheet (SDS) to be in accordance with the Regulation (EC) 1907/2006 and the Regulation (EC) 1272/2008.

      Biopak® Cartridge does not require a Safety Data Sheet (SDS) under the Occupational Health and Safety Administration Standard entitled “Hazard Communication” 29 CFR 1910.1200 for the United States of America.

      Biopak® Cartridge does not meet the criteria of a W.H.M.I.S. classification of a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required in Canada for this product.

      Disposable of wastes should be in accordance with applicable regional, national, and local laws and regulations. Do not discharge into drains or the environment, dispose to an authorized waste collection point.

      Helpful?

  2. IS THE DATE PRINTED ON THE LABEL EXPIRATION OR ELABORATION DATE? I have Ref CDUFBI001 lote F2JB93856

    1 answer

    1. The Biopak® Polisher comes with a self-adhesive label with information like Product name, Catalogue Number, Validity period, Production date, and Lot number. The Biopak® Polisher is validated for use in one operation cycle, lasting 90 days. One can also download the Certificate of Quality by mentioning the Catalogue and Lot number details from our website. The Application-pak (CDUFBI001) is intended for use as a final water purification step in the Milli-Q® water purification systems to reduce the concentration of pyrogens, RNases, DNases, and other contaminants of equal or higher molecular weight in pure or ultrapure water.

      Helpful?

  3. What is the shelf life for Filter?

    1 answer

    1. The shelf life is 2 years for all consumables kept in the recommended storage conditions (temperatures from 5 to 30°C; humidity between 10 and 80%). Contact your local representative (https://www.sigmaaldrich.com/collections/offices) for more information.

      Helpful?

  4. How are consumables changed?

    1 answer

    1. To help you to change your system's consumables, several video tutorials are available on our YouTube channel: https://youtube.com/playlist?list=PL2TUriaAaEA_IXDCnPbDk6OmrwptjwOHD. For high-flow systems, please keep in mind that all consumable changes must be approved by a 3-digit code that only the person in charge of the system knows.

      Helpful?

  5. How can I know which consumables can be used with my system?

    1 answer

    1. To know which consumables can be used on your system, you can see in the user manual of your system or see all the consumables for each system listed on https://www.sigmaaldrich.com/products/water-purification/milli-q-consumables.

      Helpful?

  6. What steps are you taking towards improved sustainability?

    1 answer

    1. Sustainability is at the heart of our innovations. From reducing water and energy consumption, to minimizing plastic and chemical waste, our dedicated water system engineers are constantly working on new ways to reduce the ecological footprint of our products to better support the sustainability goals we're all striving towards. For more information, we invite you to review the following brochure and infographic which highlight our efforts and achievements: https://www.sigmaaldrich.com/life-science/milliq#sus. Do not hesitate to contact your local representative or sales contact (https://www.sigmaaldrich.com/collections/offices) for further information.

      Helpful?

  7. Can I arrange to have my consumables automatically ordered and delivered once a year?

    1 answer

    1. It's possible to place only one consumable order per year with a specific contract called "Consumable Supply Agreement (CSA)" (https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-consumables#csa). For further information, contact your local representative or sales contact (https://www.sigmaaldrich.com/US/en/collections/offices).

      Helpful?

  8. How frequently do the various consumables need to be changed?

    1 answer

    1. The frequency that consumables must be changed depends on the system's usage (treated water volume) and on the consumables themselves (time of usage). In order to ensure the quality of water and your results, the consumables should be replaced when the system alerts you.

      Helpful?

  9. If I have a final filter that I use only occasionally (e.g., Biopak®) and have another filter (e.g. Millipak®) that I most of the time, can I keep the 'occasional-use' filter for use again at a later time?

    1 answer

    1. It is not possible to re-use a filter that has been used and then removed because air intake during replacement creates an airlock and blocks water passing through the filter. If you regularly need two different filters, we recommend using two POD dispensers.

      Helpful?

  10. Where can I find data sheets, Certificates of Origin, Certificates of Analysis, and Certificates of Quality?

    1 answer

    1. Documents and certificates are available in the "Documentation" section on this page. Do not hesitate to contact us if you require further information.

      Helpful?

1–10 of 12 Questions  

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