Skip to Content
Merck
All Photos(1)

Documents

8.55068

Sigma-Aldrich

Hydroxymethyl polystyrene

100-200 mesh, 1% DVB, Novabiochem®

Synonym(s):

Polystyrene-CH 2OH (100-200 mesh)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
13111023
NACRES:
NA.22

product name

Hydroxymethyl polystyrene (100-200 mesh), 1% DVB, Novabiochem®

Quality Level

200

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

alcohol

storage temp.

2-30°C

Related Categories

General description

This resin is ideal for the solid phase immobilization of carboxylic acids. Less cross-linking is observed than with Merrifield resin during the attachment of diacids [1]. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines [2]. Release of carboxylic acids from this support is normally effected by treatment of the resin with H For TFMSA, or by hydrogenolysis [3]. Alcohols can be liberated by reduction with DIBAL [4] or LiBH4[5]. Methyl esters can be produced by transesterification with MeONa [6] or Ti(OEt)4/CH3CO2Me [7]. Carboxamides are also accessible via Lewis acid catalyzed aminolysis [8].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] J. M. Goldwasser, et al. (1978) Can. J. Chem., 56,1562.
[2] D. J. Burdick, et al. (1993) Tetrahedron Lett., 34,2589.
[3] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
[4] M. J. Kurth, et al. (1994) J. Org. Chem., 59,5862.
[5] J. M. Stewart & J. D. Young in ′Solid Phase Peptide Synthesis, 2nd Ed.′, Rockford, Illinois, Pierce Chemical Company, 1984, pp. 92.
[6] R. Frenette, et al. (1994) Tetrahedron Lett., 35,9177.
[7] L. T. Tietze & A. Steinmetz (1996) Angew. Chem. Int. Ed.Engl., 35, 651.
[8] D. R. Barn, et al. (1996) TetrahedronLett., 37, 3213.

Linkage

Replaces: 01-64-0110

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 1.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protocols

Boc Resin Cleavage Protocol

Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.

Boc Resin Cleavage Protocol

Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.

Boc Resin Cleavage Protocol

Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.

Boc Resin Cleavage Protocol

Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service